Acute lesions of the posterior medial orbitofrontal cortex (OFC) in humans may induce a state of reality confusion marked by confabulation, disorientation, and currently inappropriate actions.This clinical state is strongly associated with an inability to abandon previously valid anticipations, that is, extinction capacity.In healthy subjects, the
GoRace: A Multi-Context and Narrative-Based Gamification Suite to Overcome Gamification Technological Challenges
Gamification is a potential approach to foster motivation and engagement in different contexts which popularity in recent years has encouraged its application in a diversity of domains, including health, education, business, society, or tourism.However, although all their promising benefits and rapidly developing, the gamification community should
Increased expression of the immunoproteasome subunits PSMB8 and PSMB9 by cancer cells correlate with better outcomes for triple-negative breast cancers
Abstract Proteasome dependency is a feature of many cancers that can be targeted by proteasome inhibitors.For some cancer types, notably breast cancer and triple-negative breast cancer (TNBC), high mRNA expression of a modified form of the proteasome, called the immunoproteasome (ImP), correlates with better outcomes and higher expression of one Im
The Effect of Chronic liver diseases on homocysteine and vitamin B12 in patients serum
Background: Homocysteine (Hcy) is a sulfur containing amino acid that is formed as an intermediary in methionine metabolism.Raised plasma homocysteine levels, which may contribute to the increased risk of chronic liver disease.Patients and Methods: Sixty two patients with Lawn Decor chronic liver disease and 26 healthy individuals were included as